Prevalence Of Metabolic Syndrome In Obese Women: Relationship Between Anthropometric Measurements And Metabolic Parameters, Exercise Prescriptions
Aim: This study aimed to investigate the prevalence of metabolic syndrome and the correlation between the altered anthropometric measurements and biochemical variables in outpatient women who applied to the Sports Physiology Clinic to obtain exercise prescriptions.
Methods: The anthropometric and biochemical parameters were obtained from 335 adult female outpatients (18-65 years old) of the clinic. Their body composition variables were determined using the bio-impedance method (Tanita BC418). The patients were then split into two groups: metabolic syndrome group (Group 1, 140 women), non-metabolic syndrome group (Group 2, 185 women). While the homogenous data were tested using the parametric Student’s t-test, the Mann-Whitney test was used for the non-homogenous data. The results were accepted to be significant if the p value was less than 0.05.
Results: A 43% of 335 patients with the Body Mass Index (BMI)>25 were coined as metabolic syndrome patients. 1.8% of women with BMI=25-29.9 (n=6), 8.4% of women with BMI=30-34.9 (n=28), 12.5% of women with BMI=35- 39.9 (n=42), and 20% of women with BMI ≥ 40 (n=67) had fit into the criteria for the metabolic syndrome. The metabolic syndrome women had a statistically higher values in percentage fat content, fat weight, fat-free content, Body Mass Index, waist circumference, systolic blood pressure, diastolic blood pressure, HbA1c, fasting blood glucose, total cholesterol, triglyceride, LDL cholesterol and insulin levels compared with the non-metabolic syndrome women. HDL cholesterol on the other hand was significantly lower in the metabolic syndrome women. In the metabolic syndrome women, there was also a positive relationship between the BMI and systolic blood pressure, but there was not with waist circumference. A significant portion (43%) of heavy/obese women who came to obtain aerobic exercise prescriptions from the Sports Physiology Clinic had fit into the criteria established for the metabolic syndrome. These women also fit into the medium/ high risk group in the risk analysis as they had altered anthropometric, biochemical and BMI variables. Our study stresses the importance of detailed risk analyses before recommending exercise prescriptions to heavy/obese women.
References
- Franklin BA, Whaley MH, Howley ET, Balady GJ. ACSM’s guidelines for exercise testing and prescription, 6th ed. Philadelphia, London, Lippincott Williams&Wilkins. 2000;25-26.
- Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Circulation. 2002 Dec 17;106 (25):3143- 421.
- Isomaa B, Almgren P, Tuomi T, Forsén B, Lahti K, Nissén M, et al. Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes care. 2001 Apr;24(4):683-9.
- Vague J. La différenciation sexuelle, facteur determinant des formes de l’obésite. Presse Med. 1947;30:339-40.
- Reaven GM. Role of insulin resistance in human disease. Diabetes 1988;37:1595-607.
- Kaplan NM. The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension. Arch Intern Med 1989;149:1514-20.
- Haffner SM, Valdez RA, Hazuda HP, Mitchell BD, Morales PA, Stern MP. Prospective analysis of the insulin-resistance syndrome (syndrome X) Diabetes 1992 Jun;41(6):715-22.
- Alberti KG. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1. Diagnosis and classification of diabetes mellitus, provisional report of a WHO consultation. Diabet Med 1998;15:539-53.
- Bethesda M.D. National Institutes of Health: Third Report of the on Detection, Evaluation and Treatment of High Blood Cholesterol Adults. Adult Treatment Panel III. Executive Summary. National Institutes of Health. National Heart Lung and Blood Institute. 2001;01:36-70.
- Alberti KG, Zimmet P, Shaw J. The metabolic syndrome-a new worldwide definition. Lancet 2005;366:1059-62.
- Worldwide definition of themetabolic syndrome. Available at: http://www. idf.org/webdata/docs/IDF. Meta syndrome definition. International Diabetes Federation. 2002 August 24.
- Fox EL, Bowers RW, Foss ML. “Beden Eğitimi ve Sporun Fizyolojik Temelleri”. Ankara, Bağıran Yayınevi. 1999;55-9.
- Gulve EA. Exercise and glycemic control in diabetes:benefits, challenges, and adjustments to pharmacotherapy. Physical Therapy 2008;88:1297-321.
- Durstine JL, Moore GE. “ACSM’s exercise management for persons with chronic disease and disabilities. Human Kinetics”. 2nd ed. Chapter 15;89-98.
- Durstine JL, Moore GE. “ACSM’s exercise management for personswith chronic disease and disabilities. Human Kinetics”. 2nd ed. Chapter 10;64-70.
- Meigs JB. Epidemiology of the metabolic syndrome. Am J Manag Care 2002;8(11 Suppl):283-92.
- Bloomgarden ZT. American Association of Clinical Endocrinologists (AACE) consensus conference on the insulin resistance syndrome: 25-26 August 2002, Washington DC, Diabetes Care 2003;26:1297-303.
- Sansoy V. Dünyada ve Türkiye‘de Metabolik Sendrom. 1.Metabolik Sendrom Sempozyumu. Antalya, 2004:13-15.
- Florkowski CM. Management of co-existing diabetes mellitus and dyslipidemia:defining the role of thiazolidinediones. Am J Cardiovasc Drugs. 2002;2:15-21.
- Cefalu WT. Insulin Resistance: Celular and clinical concepts. EBM 2001;226:13-26.
- Fulop T, Tessier D, Carpentier A. The metabolic syndrome. Pathologie Biologie, 2006;54:375- 86.
- Prasad A, Quyyumi AA. Renin-angiotensin system and angiotensin receptor blockers in the metabolic syndrome. Circulation. 2004;110:1507- 51.
- Gillum RF, Sempos CT. Ethnic variation in validity of classification of overweight and obesity using self-reported weight and height in American women and men: the Third National Health and Nutrition Examination Survey. Nutr J 2005;6:27.
- Flegal KM. Body mass index of healthy men compared with healthy women in the United States. Int J Obes 2006;30:374- 9.
- Kuczmarski RJ, Carrol MD, Flegal KM, Troiano RP. Varying body mass index cutoff points to describe overweight prevalence among U.S. adults:NHANES III (1988 to 1994). Obes Res 1997;5:542-48.
- Droyvold WB, Midthjell K, Nilsen TI, Holmen J. Change in body mass index and its impact on blood pressure: a prospective population study. Int J Obes 2005;29:650-5.
- Mancilha-Carvalho Jde J, Souza e Silva NA. The Yanomami Indians in the INTERSALT Study. Arq Bras Cardiol. 2003;80:289-300.
- Dyer AR, Elliott P. The INTERSALT study: relations of body mass index to blood pressure. INTERSALT Co-operative Research Group. J Hum Hypertens 1989;3:299-30.
- Bonora E, Targher G, Alberiche M, Bonadonna RC, Saggiani F, Zenere MB, et al. Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance andinsulin sensitivity. Diabetes Care 2000;23:57-63.
- Haffner SM, Kennedy E, Gonzalez C, Stern MP, Miettinen H. A prospective analysis of the HOMA model. The Mexico City Diabetes Study. Diabetes Care 1996;19:1138-41.
- Hanley AJ, Williams K, Stern MP, Haffner SM. Homeostasis model assessment of insulin resistance in relation to the incidence of cardiovascular disease: the San Antonio Heart Study. Diabetes Care 2002;25:1177-84.
- Galassi A, Reynold K, He J. Metbolic syndrome and risk of cardiovasculer disease: a meta analysis. Am J Med 2006;119:812-9.
- Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1:diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 1998;15:539- 53.
- Maison P. Do different dimensions of the metabolic syndrome change together over time?: Evidence supporting obesity as them central feature. Diabetes Care 2001;24:1758-63.
- Durstine JL, Moore G, Painter P, Roberts S. ACSM›s exercise management for persons with chronic diseases and disabilities by American College of Sports Medicine, 3rd edition. USA, 2009;192-99.