Infantile colic (IC) is a condition that can be defined as unexplained episodes of crying/restlessness in otherwise healthy infants. Symptoms typically begin in the first few weeks after birth and usually decrease within three months. Studies have shown that the presence of colic can lead to both short-term and long-term negative outcomes for maternal and infant health. Recognizing colic at the primary care level is possible and necessary, with a prevalence known to range between 10-40% in all infants. Although the exact etiology remains unclear, understanding theories related to the cause of colic can help clinicians to make more accurate decisions in the diagnosis and treatment process. In the differential diagnosis, alarm symptoms accompanying crying must be evaluated, and referrals should be provided when necessary. While there is no definitive cure for infantile colic, some coping methods have shown to be beneficial in reducing the severity of episodes. Parents of infants who meet diagnostic criteria for colic should be informed about the temporary nature of colic and possible treatment strategies. It is important for primary healthcare providers and families to manage the situation as a team during this process.