Tobacco addiction is a significant social problem. Therefore, smoking cessation clinics, an important step in the fight against smoking, have been established. In this case, a thyroid incidentaloma was detected in a patient presenting to a smoking cessation clinic. The aim is to emphasize that smoking is a risk factor for thyroid nodule formation and that any detected thyroid nodule should be evaluated further. A 64-year-old male patient, a 25-pack-year smoker, presented to a smoking cessation clinic with the goal of quitting smoking. During radiological evaluation, a thyroid incidentaloma was detected. He was referred to the relevant specialist. The patient was diagnosed with non-toxic multinodular goiter. Because smoking is a risk factor for thyroid nodule formation, particularly in regions with iodine deficiency, a detailed history and physical examination are crucial in smoking cessation clinics. If suspected, thyroid function tests and thyroid ultrasonography are essential for evaluation.