Objectives: In this study, we aimed to examine the know-ledge, attitudes and behaviors of intern physicians about rational drug use and drug interactions and to increase their awareness.

Materials and Methods: Data; the “physician evaluation questionnaire” and the “drug interactions knowledge level questionnaire” with the choice of true, false and I have no idea consisting of 20 correct statements prepared by the researcher were collected online.

Results: 180 students participated in the study. 59 % of the participants were female and the mean age was 23,71± 0,72. Participants stated that their level of knowledge about drugs, drug interactions and bioequivalence was low. While taking the patient’s history; they questioned vitamin, food supplements (16,7 %; n = 30) and herbal medicine (22,2 %; n = 40) at least.  The rate of those who wanted to receive training on rational drug use before graduation was 92,2 % (n = 166). The correct number of answers given to the drug interactions questionnaire is average 6,76 ± 5,57, wrong number avg. 1,29 ± 2,14, I have no idea number average. It was 11,86 ± 6,28. According to the survey, the knowledge level of physicians on drug interactions was very low (Crohnbach alpha value of 0,92). The mean number of false and no ıdea answers was significantly higher in those who received rational drug education (p = 0,027, p = 0,028).

Conclusion: The formation of rational drug use awareness and the development of educational opportunities for the expansion of educational content and timing is required to be updated dynamically.