Objective: This study aims to identify the reasons for smoking relapse, the challenges faced during the smoking cessation process, and the impact of social support on smoking cessation among individuals seeking help at a smoking cessation clinic.

Methods: This cross-sectional and descriptive study was conducted on 120 individuals who applied to the Smoking Cessation Clinic of Bolu İzzet Baysal Training and Research Hospital between April and June 2021. Participants were assessed using the Sociodemographic Data Form, the Fagerström Test for Nicotine Dependence, the Multidimensional Scale of Perceived Social Support, the UCLA Loneliness Scale, and the Beck Hopelessness Scale.

Results: Among the participants, 80% were male, and 70% were married. As the number of smoking cessation attempts increased, the perception of family support also increased (p<0.001). However, loneliness and hopelessness scores also tended to rise with repeated cessation attempts (p<0.001). A significant relationship was found between smoking relapse and social support.

Conclusion: In our study, individuals with multiple quit attempts reported higher levels of perceived social support, loneliness, and hopelessness compared with those who had attempted to quit only once. This highlights the importance of providing targeted psychological and social support interventions for individuals who have experienced multiple unsuccessful quit attempts.