The Journal of Turkish Family Physician

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Vol.11 Issue.3 · July-September 2020
Page: 102-107 Research Article 21x viewed
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Evaluation of MPV and PDW levels by using antihyperglycemic drugs in type 2 DM patients

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Published Online: 25 September 2020 · Accepted: 29 August 2020 · Received: 22 April 2020
Doi: 10.15511/tjtfp.20.00302
Cite Code: The Journal of Turkish Family Physician 2020;11(3):102-107
Authors: Hacer Dinçoğlu 1 · İrep Eray 2
1 Ankara Health Sciences University, Department of Family Medicine, MD, Ankara.
2 Ankara Bilkent City Hospital, Family Medicine Clinic, Specialist Dr., Ankara.

Please cite as: Dinçoğlu H. ve Eray İ. Tip 2 DM hastalarında antihiperglisemik ilaç kullanımı ile MPV ve PDW düzeylerinin değerlendirilmesi. Jour Turk Fam Phy 2020; 11 (3): 102-107. Doi: 10.15511/tjtfp.20.00302.


Keywords: diabetes mellitus · Rational drug use
PDF - Evaluation of MPV and PDW levels by using antihyperglycemic drugs in type 2 DM patients
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Abstract
References

Objectives: MPV and PDW are vascular complications markers and improved glycemic control levels are correlated those indicators in patients with type 2 Diabetes Mellitus. The aim of in this study, MPV and PDW levels were compared type 2 diabetic patients treated with oral antihyperglycemic agent and insulin.

Methods: This study was performed retrospectively on type 2 DM patients who were admitted to Ankara Atatürk Training and Research Hospital. 118 randomly selected patients were divided into 3 groups that were non-diabetic (Group 1), who received OAD therapy (Group 2), and those who received insulin therapy (Group 3). HbA1c, MPV, PDW levels were collected, analyzed and compared with each other.

Results: MPV and PDW values were increased in type 2 DM patients compared to the control group (Group 2; p <0.001 and Group 3 p <0.001, respectively). There was no statistically significant difference between MPV and PDW values in patients treated OAD and insulin therapy (p=0.736 ve p=0.360 respectively). A statistically significant positive correlation was found between HbA1c values and MPV (p <0.001) and PDW (p <0.001) values.

Conclusions: In our study, no significant difference was found between MPV and PDW values of patients using insulin and oad. Early initiation of conventional insulin therapy in patients with type 2 diabetes provides good glycemic control. Rational drug use in accordance with the guidelines; gains importance in treatment success. Skipping this factor may reduce the efficiency of other efforts in relation to rational treatment.

References

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